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  6. BubR1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

BubR1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Product Code. 16808633 Shop All Proteintech Products
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20 μL
150 μL
Unit Size:
150µL
20µL
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16808633 150 μL 150µL
16818633 20 μL 20µL
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Product Code. 16808633 Supplier Proteintech Supplier No. 115042AP150UL

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Description

Rabbit Polyclonal Antibody

BUBR1 is a member of the Ser/Thr protein kinase family. It is a component of the mitotic checkpoint that delays anaphase until all chromosome are properly attached to the mitotic spindle. Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to maligt transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.

Specifications

Antigen BubR1
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene BUB1B
Gene Accession No. O60566, Q9Z1S0
Gene Alias Bub1A, BUB1B, BUB1beta, BubR1, hBUBR1, MAD3L, Protein SSK1, SSK1
Gene Symbols BUB1B
Host Species Rabbit
Immunogen BubR1 Fusion Protein Ag2053
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12236, 701
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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