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BMX-IN-1, MedChemExpress

Product Code. 16400698
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Product Code. 16400698

Brand: Medchem Express HY80002

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Description

MedChemExpress BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.

BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.

Specifications

Chemical Name or Material BMX-IN-1
CAS 1431525-23-3
Color Off-White
Purity Grade Notes Research
Molecular Formula C29H24N4O4S
Quantity 5 mg
Synonym BMX kinase inhibitor
Solubility Information DMF : 10 mg/mL (19.06 mM; Need ultrasonic) ∣DMSO : 8.33 mg/mL (15.88 mM; Need ultrasonic)
SMILES O=C1N(C2=C(C=C1)C=NC3=CC=C(C4=CC=C(NS(=O)(C)=O)C=C4)C=C32)C5=CC=C(C)C(NC(C=C)=O)=C5
Molecular Weight (g/mol) 524.59
Formula Weight 524.59
Percent Purity 96.27%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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