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Birinapant, MedChemExpress

Product Code. 16459637
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Product Code. 16459637 Supplier Medchem Express Supplier No. HY16591

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Description

MedChemExpress Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with Kds of 45 nM and less than 1 nM, respectively.

Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-κB activation.

Specifications

Chemical Name or Material Birinapant
CAS 1260251-31-7
Color Off-White
Purity Grade Notes Research
Molecular Formula C42H56F2N8O6
Quantity 5 mg
Synonym TL32711
Solubility Information DMSO : 125 mg/mL (154.91 mM; Need ultrasonic)
SMILES FC1=CC2=C(C=C1)C(C[C@H]3N(C([C@@H](NC([C@@H](NC)C)=O)CC)=O)C[C@@H](O)C3)=C(C(N4)=C(C[C@H]5N(C([C@@H](NC([C@@H](NC)C)=O)CC)=O)C[C@@H](O)C5)C6=C4C=C(F)C=C6)N2
Molecular Weight (g/mol) 806.94
Formula Weight 806.94
Percent Purity 96.01%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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