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STEMCELL Technologies BIRB-796

Product Code. 17190102
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Product Code. 17190102 Supplier STEMCELL Technologies Supplier No. 72682

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Description

p38 MAPK inhibitor

  • BIRB-796 is a highly potent inhibitor of p38 MAPK (Kd = 0.1 nM) that blocks TNFα release in LPS-stimulated THP-1 cells (IC50 = 18 nM) (Pargellis et al.) At 10 μM, BIRB-796 can also inhibit JNK2α2 in vitro, but at lower concentrations BIRB-796 inhibits p38 MAPK without affecting phosphorylation of JNK substrates (Bain et al.; Kuma et al.)
  • Rescues the self-renewal ability of muscle satellite cells from aged mice (Bernet et al.)
  • Increases the regenerative capacity of functional aged skeletal muscle stem cells grown in hydrogel (Cosgrove et al.)
  • Blocks GADD45G-induced differentiation of long-term repopulating hematopoietic stem cells (Thalheimer et al.)
  • Enhances stem cell activity of cultured umbilical cord blood-derived hematopoietic cells cultured in serum-free medium supplemented with SCF, TPO, and FLT3L (Baudet et al.)
  • Blocks the osteogenic differentiation effect of myocilin on human mesenchymal stem cells (Kwon et al.)

Specifications

CAS 285983-48-4
Synonym Doramapimod
Quantity 1 mg
Molecular Formula C31H37N5O3
Purity ≥98%
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