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beta-Estradiol, 99% (dry wt.), ca 3% water

Product Code. 11376656
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Product Code. 11376656 Supplier Thermo Scientific Alfa Aesar Supplier No. L03801.06
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Description

CAS: 50-28-2 | C18H24O2 | 272.388 g/mol

β-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner's syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
β-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner′s syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.

Solubility
Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.

Notes
Incompatible with strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 50-28-2
Molecular Formula C18H24O2
Molecular Weight (g/mol) 272.388
MDL Number MFCD00003693
InChI Key VOXZDWNPVJITMN-ZBRFXRBCSA-N
Synonym estradiol, beta-estradiol, 17beta-estradiol, oestradiol, dihydrofolliculin, estrace, ovocyclin, progynon, dihydrotheelin, dihydroxyestrin
PubChem CID 5757
ChEBI CHEBI:16469
IUPAC Name (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
SMILES CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

Specifications

Melting Point 175°C to 178°C
Quantity 5 g
Beilstein 1914275
Merck Index 14,3703
Solubility Information Soluble in dimethyl sulfoxide,ethanol ,water,phosphate buffer saline,dimethyl formamide,acetone,dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Optical Rotation +79° (c=1 in Dioxane)
Formula Weight 272.39
Percent Purity 99%
Assay (dry wt.), ≈3% water
Chemical Name or Material beta-Estradiol

RUO – Research Use Only

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