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  7. BAY 61-3606 dihydrochloride, MedChemExpress

BAY 61-3606 dihydrochloride, MedChemExpress

Product Code. 16476278
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Product Code. 16476278

Brand: Medchem Express HY14985

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Description

MedChemExpress BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM an IC50 of 10 nM.

BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.

Specifications

Chemical Name or Material BAY 61-3606 dihydrochloride
CAS 648903-57-5
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C20H20Cl2N6O3
Quantity 10 mg
Solubility Information H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMILES O=C(N)C1=CC=CN=C1NC2=NC(C3=CC=C(C(OC)=C3)OC)=CC4=NC=CN24.[H]Cl.[H]Cl
Molecular Weight (g/mol) 463.32
Formula Weight 463.32
Percent Purity 98.21%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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