B7-H3 Monoclonal Antibody (6A1), Invitrogen™

Description

MA5-15693 targets CD276 in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human samples. The MA5-15693 immunogen is purified recombinant fragment of human CD276 expressed in E. Coli. MA5-15693 detects CD276 which has a predicted molecular weight of approximately 57kDa.

CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3. CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.