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Invitrogen™ Aquaporin 2 Polyclonal Antibody
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Product Code. 13218038
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
13218038 100 μL 100µL
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Product Code. 13218038 Supplier Invitrogen™ Supplier No. PA522865

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Description

Rabbit Polyclonal Antibody

In Western blot, bands can be seen ~28 kDa for the non-glycosylated form and ~37 kDa for the glycosylated form. Suggested positive control: rat kidney, renal inner medulla.

Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans. A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells. Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Aquaporin 2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Aqp2
Gene Accession No. P34080, P41181, P56402, P79099
Gene Alias ADH water channel; AQP 2; AQP CD; Aqp2; AQP-2; AQPCD; AQP-CD; aquaporin 2; aquaporin 2 (collecting duct); Aquaporin CD; Aquaporin2; aquaporin-2; Aquaporin-CD; Aquaporine 2; collecting duct water channel protein; cph; jpk; MGC34501; Water channel protein for renal collecting duct; water-channel aquaporin 2; WCH CD; WCHCD; WCH-CD
Gene Symbols Aqp2
Host Species Rabbit
Immunogen Synthetic peptide made to a C-terminus portion of rat Aquaporin-2 (within residues 200-300).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100147810, 11827, 25386, 359, 539870
Target Species Human, Mouse, Rat, Bovine, Pig
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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