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Invitrogen™ APS Polyclonal Antibody
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Product Code. 15740122 Shop All Thermo Scientific Products
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Quantity:
100 μL
Unit Size:
100µL
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15740122 100 μL 100µL
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Product Code. 15740122 Supplier Invitrogen™ Supplier No. PA562326

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RDKWTRRLRL SRTLAAKVEL VDIQREGALR FMVADD Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

APS (adapter protein with Pleckstrin homology and Src homology 2 domains) a member of the Lnk family, is an adaptor protein that is involved in B-cell signaling, insulin signaling, cytoskeletal reorganization. It is tyrosine phosphorylated by JAK2, KIT and other kinases during B-cell receptor stimulation of many different cytokines, chemokines and leukokines. APS has been shown to inhibit the JAK-STAT pathway in collaboration with c-Cbl. It is located in the cytoplasm in pre-PDGF (platelet derived growth factor) stimulated cells and localizes to the plasma membrane and peripheral regions upon PDGF stimulation. This protein is expressed in B-cells and mast cells when detected in haematopoietic cell lines yet is also expressed in many different tissues including spleen, prostrate, testis, uterus, small intestine and skeletal muscle.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APS
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SH2B2
Gene Accession No. O14492
Gene Alias adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleckstrin homology and src homology 2 domains; Alpha-1-antitrypsin; Aps; SH2 and PH domain-containing adapter protein APS; SH2B adapter protein 2; SH2B adaptor protein 2; Sh2b2
Gene Symbols SH2B2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human APS. Recombinant protein control fragment (Product #RP-99507).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10603
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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