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VASP Mouse, Unlabeled, Clone: 43, BD

Product Code. 15825469
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150 μg
50 μg
Unit Size:
1 set
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15825469 50 μg 1 set
15835469 150 μg 1 set
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Product Code. 15825469 Supplier BD Biosciences Supplier No. 610447

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Mouse Monoclonal Antibody

Vasodilator-stimulated phosphoprotein (VASP), a substrate for cAMP- and cGMP-dependent kinases, is associated with actin filaments, focal adhesions, and dynamic membrane regions. VASP is composed of several distinct domains: a central L-proline-rich domain contains a GPPPPP motif as a single copy and as a three-fold tandem repeat, as well as three conserved phosphorylation sites for cyclic nucleotide-dependent protein kinases (Ser157, Ser239, and Thr278). A C-terminal domain contains a repetitive mixed-charge cluster which is predicted to form an α-helix. The C-terminal domain appears to be responsible for anchoring at focal adhesion sites. VASP has been shown to be a ligand for profilins. Profilins bind to the poly-L-proline motifs of VASP and it is postulated that these two molecules act in concert to convey signal transduction to actin filament formation.

Immunofluorescence, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen VASP
Applications Western Blot
Classification Monoclonal
Clone 43
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Human
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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