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  6. Paxillin Mouse, Unlabeled, Clone: 349, BD

Paxillin Mouse, Unlabeled, Clone: 349, BD

Product Code. 15845229
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Quantity:
150 μg
50 μg
Unit Size:
1 set
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15845229 50 μg 1 set
15855229 150 μg 1 set
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Product Code. 15845229 Supplier BD Biosciences Supplier No. 610051

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Description

Mouse Monoclonal Antibody

A number of cytoskeletal proteins are tyrosine phosphorylated in Rous sarcoma virus-transformed chick embryo fibroblasts. One of these is the 68 kDa paxillin protein. Paxillin is a cytoskeletal component that localizes to the focal adhesions at the ends of actin stress fibers. It is also present in the focal adhesions of Madin-Darby canine kidney epithelial cells, but is absent from the cell adherens junctions of these cells. Paxillin purified from chicken gizzard migrates as a diffuse band on SDS-PAGE with molecular weight of 65-70 kDa. It binds to the rod domain of vinculin, another focal adhesion protein. It is thought that phosphorylation of paxillin may have a role in that disassembly of focal adhesions and stress fibers during transformation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Paxillin
Applications Western Blot
Classification Monoclonal
Clone 349
Concentration 1.0mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing glycerol and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Chicken Paxillin aa. 1 to 557
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Chicken, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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