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  6. NCK Mouse, Unlabeled, Clone: 108, BD

NCK Mouse, Unlabeled, Clone: 108, BD

Product Code. 15835259
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Quantity:
50 μg
Unit Size:
1 set
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15835259 50 μg 1 set
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Product Code. 15835259 Supplier BD Biosciences Supplier No. 610099

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Description

Mouse Monoclonal Antibody

NCK is a 47kDa protein that belongs to a class of signaling molecules called adaptors. These proteins exert their effects by coupling activated receptors to downstream effectors. NCK is comprised almost entirely of one SH2 and three SH3 domains and it possesses no intrinsic catalytic activity. Investigations of its interactions with cellular proteins have found constitutive association of NCK with various Ser/THr kinases, such as p21-associated kinase (PAK) and casein kinase 1. Other proteins that directly interact with NCK are: Sos, Cbl, Wiskott-Aldrich syndrome protein (WASP), IRS1, and multiple tyrosine kinase receptors. The presence of NCK is necessary for the mitogenic response elicited by PDGF in some cells. In addition, the Drosophila homologue of NCK is involved in regulating cytoskeletal organization.

Host Species: Mouse
Clone: 108
Isotype: IgG2b
Species Reactivity: Human
Immunogen: Human NCK aa. 279-377
Formula Weight [Chemical]: 47kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen NCK
Applications Western Blot
Classification Monoclonal
Clone 108
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human NCK aa. 279-377
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Bovine, Canine, Chicken, Frog, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG2b
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For Research Use Only.

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