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Description
Reacts with a 600kDa, type I membrane single protein, also known as the α2 Macroglobulin (α2M) receptor/low density lipoprotein (LDL) receptor. The single chain receptor undergoes cleavage, shortly after synthesis, into the 85kDa transmembrane β chain that non-covalently binds to the extracellular 500-515kDa a chain. It has a broad cellular distribution, but in the hematopoietic system it is expressed on monocyte lineage cells. The α2M/LDL receptor mediates endocytosis of a variety of ligands including α2M-proteinase complexes, plasminogen activators in complex with plasminogen activator inhibitor, Pseudomonas Exotoxin A. Ligand binding to α2M/LDL receptor is followed by rapid transport of the ligand to lysosomes for degradation.
Host Species: Mouse
Clone: A2MR-α2
Isotype: IgG1 κ
Species Reactivity: Human
Flow Cytometry
Specifications
| CD91 | |
| Monoclonal | |
| PE | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| A2MR-A2 | |
| Alpha-2-macroglobulin receptor; α2MR; LRP-1; LDL Receptor-Related Protein-1 | |
| Mouse | |
| 100 Tests | |
| Immunology | |
| Human | |
| IgG1 κ |
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