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Description
The RM4-4 antibody reacts with the CD4 (L3T4) differentiation antigen expressed on most thymocytes, a subpopulation of mature T lymphocytes (i.e., MHC class II-restricted T cells, including most T helper cells), and a subset of NK-T cells of all mouse strains tested. CD4 has also been detected at low density on pluripotent hematopoietic stem cells, bone marrow myeloid and B-lymphocyte precursors, intrathymic lymphoid precursors, and a subset of splenic dendritic cells. CD4 is expressed on the plasma membrane of mouse egg cells and is involved in adhesion of the egg to MHC class II-bearing sperm. CD4 is an antigen coreceptor on the T-cell surface which interacts with MHC class II molecules on antigen-presenting cells. It participates in T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase lck. Purified RM4-4 mAb does not block binding of FITC-conjugated GK1.5 mAb (Cat. No. 557307/553729), H129.19 mAb (Cat. No. 553650/553651), or RM4-5 mAb (Cat. No. 553046/553047) to T cells.
This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
Specifications
| CD4 | |
| Monoclonal | |
| 0.5mg/mL | |
| L3T4 | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Mouse | |
| IgG2b κ |
| Flow Cytometry | |
| RM4-4 | |
| Unconjugated | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| BALB/c mouse thymocytes | |
| 0.5 mg | |
| Primary | |
| Store undiluted at 4°C |
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