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Invitrogen™ Alivin 1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA14357
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Description
PA1-4357 detects the alivin 1 protein in mouse and rat samples. PA1-4357 has been successfully used in Western blot procedures. By Western blot this antibody detects bands of ~63 and 66 kDa representing alivin 1 in mouse brain lysate. The PA1-4357 immunogen is a synthetic peptide correspondiing to residues T(449) G D A S A D D R K A G K R V V(464) of mouse and rat alivin 1. There is 81% sequence identity to human.
A novel primary response gene, Alivin 1 (ali1), is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human Ali1 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families. Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.
Specifications
| Alivin 1 | |
| Polyclonal | |
| Unconjugated | |
| Amigo2 | |
| adhesion molecule with Ig like domain 2; adhesion molecule with Ig-like domain 2; AI415330; Ali1; alivin 1; alivin-1; amigo2; AMIGO-2; amigo2 {ECO:0000312; amphoterin induced gene 2; amphoterin induced gene and ORF 2; amphoterin-induced protein 2; AW208913; DEGA; differentially expressed in gastric adenocarcinoma; differentially expressed in gastric adenocarcinomas; EMBL:AAO48951.1}; transmembrane protein AMIGO2 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 105827, 300186 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| Q7TNJ4, Q80ZD9 | |
| Amigo2 | |
| Synthetic peptide corresponding to residues T(449) G D A S A D D R K A G K R V V(464) of mouse and rat alivin 1. | |
| 100 μg | |
| Primary | |
| Mouse, Rat | |
| Antibody | |
| IgG |
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