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Alisertib, MedChemExpress

Product Code. p-200099805
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Product Code. 16497037

Brand: Medchem Express HY10971

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Description

MedChemExpress Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity.

Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity.

Specifications

Chemical Name or Material Alisertib
CAS 1028486-01-2
Color Light Nude
Purity Grade Notes Research
Molecular Formula C27H20ClFN4O4
Quantity 5 mg
Synonym MLN 8237
Solubility Information DMSO : 25 mg/mL (48.18 mM; Need ultrasonic)
SMILES O=C(C1=CC=C(C=C1OC)NC2=NC=C3CN=C(C4=CC(Cl)=CC=C4C3=N2)C5=C(C=CC=C5F)OC)O
Molecular Weight (g/mol) 518.92
Formula Weight 518.92
Percent Purity 95.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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