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Tocris Bioscience™ a-Synuclein Degrader 2b

Product Code. 18704444
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Product Code. 18704444 Supplier Tocris Bioscience™ Supplier No. 8040/5

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382.50 EUR valid until 2026-03-31
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Description

α-synuclein Degrader (PROTAC™)

α-Synuclein Degrader 2b is a selective α-synuclein Degrader (PROTAC™) (DC50 = 7.5 μM; Dmax = 89%). Comprises the probe molecule sery308, joined by a linker to a pomalidomide E3 ligase ligand. Activates both proteasomal and lysosomal degradation pathways. Protects SH-SY5Y cells from α-synuclein-induced cytotoxicity. Cell permeable.PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide
CAS 2781922-42-5
Quantity 5 mg
Target Active Degraders
Molecular Formula C39H41N7O10
Purity 0.98
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