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  6. 3,3',5-Triiodo-L-thyronine, 95%

3,3',5-Triiodo-L-thyronine, 95%

Product Code. 15496977
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Product Code. 15496977 Supplier Thermo Scientific Alfa Aesar Supplier No. H34068.MD
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Description

CAS: 6893-02-3 | C15H12I3NO4 | 650.98 g/mol

Using video intensification fluorescence microscopy and tetramethylrhodamine (Rho)-labeled 3, 3', 5-triiodo-L-thyronine (T3),the uptake of T3 by cultured mouse fibroblasts was studied. The binding of 3, 3', 5-triiodo-L-thyronine (T3) to GH3 rat pituitary tumor cells was studied at 15 degrees C and was shown to be saturable, reversible, and stereospecific. A fluorescent derivative of the thyroid hormone 3,3'-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. 3,3?,5-Triiodo-L-thyronine Up-regulation of Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial Cells Is Src Kinase- and Phosphoinositide 3-Kinase-dependent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Using video intensification fluorescence microscopy and tetramethylrhodamine (Rho)-labeled 3, 3′, 5-triiodo-L-thyronine (T3),the uptake of T3 by cultured mouse fibroblasts was studied. The binding of 3, 3′, 5-triiodo-L-thyronine (T3) to GH3 rat pituitary tumor cells was studied at 15 degrees C and was shown to be saturable, reversible, and stereospecific. A fluorescent derivative of the thyroid hormone 3,3′-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. 3,3′,5-Triiodo-L-thyronine Up-regulation of Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial Cells Is Src Kinase- and Phosphoinositide 3-Kinase-dependent.

Solubility
Insoluble in water, ethanol and propylene glycol. Soluble in dilute alkalies.

Notes
Light Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, Strong bases, light.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 6893-02-3
Molecular Formula C15H12I3NO4
Molecular Weight (g/mol) 650.98
MDL Number MFCD00002593
InChI Key AUYYCJSJGJYCDS-UHFFFAOYNA-N
Synonym liothyronine, triiodothyronine, 3,3',5-triiodo-l-thyronine, liothyronin, tresitope, 3,5,3'-triiodothyronine, l-liothyronine, triothyrone, liothyroninum, liotironina
PubChem CID 5920
ChEBI CHEBI:18258
IUPAC Name (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
SMILES C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O

Specifications

Melting Point 234°C to 238°C
Quantity 250 mg
Sensitivity Light sensitive
Solubility Information Insoluble in water,ethanol and propylene glycol. Soluble in dilute alkalies.
Optical Rotation +25° (c=1 in 1M HCl/Ethanol 1:2)
Formula Weight 650.97
Percent Purity 95%
Chemical Name or Material 3,3',5-Triiodo-L-thyronine

Safety and Handling

compliance-icons
Product Identifier
  • 3,3',5-Triiodo-L-thyronine
 Signal Word
  • Warning
 Hazard Category
  • Serious eye damage/eye irritation Category 2
  • Skin corrosion/irritation Category 2
  • Specific target organ toxicity Category 3
 Hazard Statement
  • H315-Causes skin irritation.
  • H319-Causes serious eye irritation.
  • H335-May cause respiratory irritation.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
  • P332+P313-If skin irritation occurs: Get medical advice/attention.
  • P337+P313-If eye irritation persists: Get medical advice/attention.
 Supplemental information
  • MIXTURE LIST-Contains : Liothyronine
SDS

RUO – Research Use Only

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