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2-Iodoacetamide, 98%, stab. with ca 5-8% water
Description
Alkylating agent used in peptide mapping because it covalently binds with the thiols in cysteine to prevent disulfide bond formation2-Iodoacetamide is used as an electrophile for covalent modification of nucleophilic residues on proteins such as cysteine, methionine and histidine. It is used to bind with thiol group of cysteine, thereby it protects the formation disulfide bonds. It is involved as an inhibitor of deubiquitinase enzymes (DUBs). Further, it acts as an alkylating sulfhydryl reagent.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Alkylating agent used in peptide mapping because it covalently binds with the thiols in cysteine to prevent disulfide bond formation2-Iodoacetamide is used as an electrophile for covalent modification of nucleophilic residues on proteins such as cysteine, methionine and histidine. It is used to bind with thiol group of cysteine, thereby it protects the formation disulfide bonds. It is involved as an inhibitor of deubiquitinase enzymes (DUBs). Further, it acts as an alkylating sulfhydryl reagent.
Solubility
Soluble in water, dimethyl formamide and ethanol. Slightly soluble in methanol.
Notes
Store in a cool place. Light and moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.
Spécification
Spécification
| Melting Point | 92°C to 95°C (dried) |
| Assay Percent Range | 98%, stabilized with ca 5% water |
| Odor | Characteristic |
| Quantity | 100 g |
| UN Number | UN2811 |
| Beilstein | 1739080 |
| Sensitivity | Light sensitive |
| Solubility Information | Soluble in water,dimethyl formamide and ethanol. Slightly soluble in methanol. |
| Formula Weight | 184.96 |
| Percent Purity | 98% |
| Afficher plus |
Sécurité et traitement
- 2-Iodoacetamide
- Danger
- Acute toxicity Category 3
- Serious eye damage/eye irritation Category 1
- Respiratory sensitiser Category 1
- Skin corrosion/irritation Category 1 B
- Skin sensitiser Category 1
- H301-Toxic if swallowed.
- H314-Causes severe skin burns and eye damage.
- H317-May cause an allergic skin reaction.
- H318-Causes serious eye damage.
- H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
- P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P310-Immediately call a POISON CENTER/doctor/.
- MIXTURE LIST-Contains : 2-Iodoacetamide
RUO – Research Use Only
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