CAS RN 1290543-63-3

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Nirogacestat, MedChemExpress

MedChemExpress Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers.

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Specifications

Molecular Weight (g/mol)	489.64
Color	White
Physical Form	Solid
Chemical Name or Material	Nirogacestat
Grade	Research
SMILES	FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1
For Use With (Application)	Cancer-programmed cell death
Percent Purity	97.5%
CAS	1290543-63-3
Solubility Information	DMSO : 28.57 mg/mL (58.35 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Health Hazard 1	H315∣H319∣H335
Synonym	PF-3084014 PF-03084014
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₇H₄₁F₂N₅O
Formula Weight	489.64

CAS RN 1290543-63-3

CAS RN 1290543-63-3

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