Pyrroles

Aromatic organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that forms an amine functional group.

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1 – 15 of 184 results

SB269652, MedChemExpress

MedChemExpress SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.

Pricing and Availability

Apyramide, MedChemExpress

MedChemExpress Apyramide is an anti-inflammatory agent (NSAID) and behaves as a prodrug of indomethacin (HY-14397). Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	490.93
Color	White
Physical Form	Solid
Chemical Name or Material	Apyramide
Grade	Research
SMILES	O=C(OC1=CC=C(NC(C)=O)C=C1)CC2=C(C)N(C(C3=CC=C(Cl)C=C3)=O)C4=C2C=C(OC)C=C4
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.06%
CAS	68483-33-0
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₇H₂₃ClN₂O₅
Formula Weight	490.93

Oncrasin-1, MedChemExpress

MedChemExpress Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	269.73
Color	Earth Yellow
Physical Form	Solid
Chemical Name or Material	Oncrasin-1
Grade	Research
SMILES	O=CC1=CN(CC(C=C2)=CC=C2Cl)C3=CC=CC=C31
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.28%
CAS	75629-57-1
Solubility Information	DMSO : ≥ 43 mg/mL (159.42 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₆H₁₂ClNO
Formula Weight	269.73

Vinburnine, MedChemExpress

MedChemExpress Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.

Pricing and Availability

Staurosporine, MedChemExpress

MedChemExpress Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	466.53
Color	Light Yellow
Physical Form	Powder
Chemical Name or Material	Staurosporine
Grade	Research
SMILES	O=C(NC1)C2=C1C3=C(C4=C2C5=C(C=CC=C5)N4[C@H]6C[C@@H](NC)[C@@H](OC)[C@]7(C)O6)N7C8=CC=CC=C83
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.0%
CAS	62996-74-1
Solubility Information	DMSO : 62.5 mg/mL (133.97 mM; Need ultrasonic)
Synonym	Antibiotic AM-2282 STS AM-2282
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₈H₂₆N₄O₃
Formula Weight	466.53

RG7713, MedChemExpress

MedChemExpress RG7713 (RO5028442) is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	437.96
Color	White
Physical Form	Solid
Chemical Name or Material	RG7713
Grade	Research
SMILES	O=C(C1=CN(CCN(C)C)C2=C1C=CC(Cl)=C2)N3CCC4(C(C=CC=C5)=C5CO4)CC3
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	99.79%
CAS	920022-47-5
Solubility Information	DMSO : 20 mg/mL (45.67 mM; Need ultrasonic)
Synonym	RO5028442
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₂₈ClN₃O₂
Formula Weight	437.96

Ribociclib, MedChemExpress

MedChemExpress Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	434.54
Color	Light Yellow
Physical Form	Powder
Chemical Name or Material	Ribociclib
Grade	Research
SMILES	O=C(N(C)C)C(N1C2CCCC2)=CC(C1=N3)=CN=C3NC(N=C4)=CC=C4N5CCNCC5
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.52%
CAS	1211441-98-3
Solubility Information	DMSO : 20 mg/mL (46.03 mM; Need ultrasonic)
Synonym	LEE011
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₃H₃₀N₈O
Formula Weight	434.54

JNJ-7777120, MedChemExpress

MedChemExpress JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	277.75
Color	White
Physical Form	Solid
Chemical Name or Material	JNJ-7777120
Grade	Research
SMILES	O=C(C(N1)=CC2=C1C=CC(Cl)=C2)N3CCN(C)CC3
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.0%
CAS	459168-41-3
Solubility Information	DMSO : ≥ 50 mg/mL (180.02 mM)
Health Hazard 1	H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₄H₁₆ClN₃O
Formula Weight	277.75

Amcasertib, MedChemExpress

MedChemExpress Amcasertib (BBI503) is an orally active and small-molecule multi-kinase inhibitor. Amcasertib exhibits inhibitory activity against the NANOG and CD133 expression and cell viability in PC-9/GR cells. As an orally available cancer cell stemness kinase inhibitor with potential antineoplastic activity, it is currently being studied in phase I clinical trials in a number of cancers.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	539.69
Color	Yellow
Physical Form	Solid
Chemical Name or Material	Amcasertib
Grade	Research
SMILES	O=C(C1=C(C)NC(/C=C2C(NC3=C/2C=C(C4=CSC(C5=CC=CC=C5)=N4)C=C3)=O)=C1C)NCCN(CC)CC
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.15%
CAS	1129403-56-0
Solubility Information	DMSO : ≥ 30 mg/mL (55.59 mM)
Synonym	BBI503
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₁H₃₃N₅O₂S
Formula Weight	539.69

LY2452473, MedChemExpress

MedChemExpress LY2452473 is an orally bioavailable, selective androgen receptor modulator (SARM).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	374.44
Color	Off-White
Physical Form	Solid
Chemical Name or Material	LY2452473
Grade	Research
SMILES	O=C(N[C@@H]1CC(N(C2=C3C=C(C=C2)C#N)CC4=NC=CC=C4)=C3C1)OC(C)C
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.13%
CAS	1029692-15-6
Solubility Information	DMSO : 62.5 mg/mL (166.92 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₂H₂₂N₄O₂
Formula Weight	374.44

AZ191, MedChemExpress

MedChemExpress AZ191 is a potent inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	429.52
Color	Brown
Physical Form	Solid
Chemical Name or Material	AZ191
Grade	Research
SMILES	CN1C2=CN=CC=C2C(C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3)=C1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.7%
CAS	1594092-37-1
Solubility Information	DMSO : ≥ 30 mg/mL (69.85 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₂₇N₇O
Formula Weight	429.52

KY1220, MedChemExpress

MedChemExpress KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	314.32
Color	Yellow
Physical Form	Solid
Chemical Name or Material	KY1220
Grade	Research
SMILES	O=C(/C(N1)=C/C2=CC=CN2C3=CC=C([N+]([O-])=O)C=C3)NC1=S
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.0%
CAS	292168-79-7
Solubility Information	DMSO : ≥ 100 mg/mL (318.15 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₄H₁₀N₄O₃S
Formula Weight	314.32

GSK376501A, MedChemExpress

MedChemExpress GSK376501A is a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator for the treatment of type 2 diabetes mellitus.

Pricing and Availability

UNC2025, MedChemExpress

MedChemExpress UNC2025 is a potent, ATP-competitive and highly orally active Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 is >45-fold selectivity for MERTK relative to Axl (IC50= 122 nM; Ki = 13.3 nM). UNC2025 exhibits an excellent PK properties, and can be used for the investigation of acute leukemia.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	476.66
Color	White
Physical Form	Solid
Chemical Name or Material	UNC2025
Grade	Research
SMILES	CN1CCN(CC2=CC=C(C3=CN([C@@H]4CC[C@@H](O)CC4)C5=NC(NCCCC)=NC=C53)C=C2)CC1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	96.86%
CAS	1429881-91-3
Solubility Information	DMSO : 33.33 mg/mL (69.92 mM; Need ultrasonic and warming)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₈H₄₀N₆O
Formula Weight	476.66

MDL-29951, MedChemExpress

MedChemExpress MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	302.11
Color	Off-White
Physical Form	Solid
Chemical Name or Material	MDL-29951
Grade	Research
SMILES	O=C(O)CCC1=C(C(O)=O)NC2=C1C(Cl)=CC(Cl)=C2
For Use With (Application)	Neuroscience-Neurodegeneration
Percent Purity	99.5%
CAS	130798-51-5
Solubility Information	DMSO : ≥ 50 mg/mL (165.50 mM)
Health Hazard 1	H302∣H317
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₂H₉Cl₂NO₄
Formula Weight	302.11

Pyrroles

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