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Filtered Search Results
Staurosporine, MedChemExpress
MedChemExpress Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer.
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| Molecular Weight (g/mol) | 466.53 |
|---|---|
| Color | Light Yellow |
| Physical Form | Powder |
| Chemical Name or Material | Staurosporine |
| Grade | Research |
| SMILES | O=C(NC1)C2=C1C3=C(C4=C2C5=C(C=CC=C5)N4[C@H]6C[C@@H](NC)[C@@H](OC)[C@]7(C)O6)N7C8=CC=CC=C83 |
| For Use With (Application) | Cancer-Kinase/protease |
| Percent Purity | 98.0% |
| CAS | 62996-74-1 |
| Solubility Information | DMSO : 62.5 mg/mL (133.97 mM; Need ultrasonic) |
| Synonym | Antibiotic AM-2282 STS AM-2282 |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C28H26N4O3 |
| Formula Weight | 466.53 |
Vinburnine, MedChemExpress
MedChemExpress Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.
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SB269652, MedChemExpress
MedChemExpress SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.
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Metergoline, MedChemExpress
MedChemExpress Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation.
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| Molecular Weight (g/mol) | 403.52 |
|---|---|
| Color | White |
| Physical Form | Solid |
| Chemical Name or Material | Metergoline |
| Grade | Research |
| SMILES | O=C(OCC1=CC=CC=C1)NC[C@H](C[C@@]23[H])CN(C)[C@]2([H])CC4=CN(C)C5=CC=CC3=C54 |
| For Use With (Application) | Neuroscience-Neuromodulation |
| Percent Purity | 98.62% |
| CAS | 17692-51-2 |
| Solubility Information | DMSO : 125 mg/mL (309.77 mM; Need ultrasonic) |
| Health Hazard 1 | H302∣H312∣H332 |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C25H29N3O2 |
| Formula Weight | 403.52 |
Apyramide, MedChemExpress
MedChemExpress Apyramide is an anti-inflammatory agent (NSAID) and behaves as a prodrug of indomethacin (HY-14397). Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2.
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| Molecular Weight (g/mol) | 490.93 |
|---|---|
| Color | White |
| Physical Form | Solid |
| Chemical Name or Material | Apyramide |
| Grade | Research |
| SMILES | O=C(OC1=CC=C(NC(C)=O)C=C1)CC2=C(C)N(C(C3=CC=C(Cl)C=C3)=O)C4=C2C=C(OC)C=C4 |
| For Use With (Application) | COVID-19-immunoregulation |
| Percent Purity | 99.06% |
| CAS | 68483-33-0 |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C27H23ClN2O5 |
| Formula Weight | 490.93 |
Oncrasin-1, MedChemExpress
MedChemExpress Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.
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| Molecular Weight (g/mol) | 269.73 |
|---|---|
| Color | Earth Yellow |
| Physical Form | Solid |
| Chemical Name or Material | Oncrasin-1 |
| Grade | Research |
| SMILES | O=CC1=CN(CC(C=C2)=CC=C2Cl)C3=CC=CC=C31 |
| For Use With (Application) | Cancer-Kinase/protease |
| Percent Purity | 98.28% |
| CAS | 75629-57-1 |
| Solubility Information | DMSO : ≥ 43 mg/mL (159.42 mM) |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C16H12ClNO |
| Formula Weight | 269.73 |
PCI-34051, MedChemExpress
MedChemExpress PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.
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| Molecular Weight (g/mol) | 296.32 |
|---|---|
| Color | Off-White |
| Physical Form | Solid |
| Chemical Name or Material | PCI-34051 |
| Grade | Research |
| SMILES | COC(C=C1)=CC=C1CN2C3=CC(C(NO)=O)=CC=C3C=C2 |
| For Use With (Application) | Cancer-programmed cell death |
| Percent Purity | 97.28% |
| CAS | 950762-95-5 |
| Solubility Information | DMSO : ≥ 30 mg/mL (101.24 mM) |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C17H16N2O3 |
| Formula Weight | 296.32 |
UBCS039, MedChemExpress
MedChemExpress UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM.
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| Molecular Weight (g/mol) | 247.29 |
|---|---|
| Color | Light Yellow |
| Physical Form | Powder |
| Chemical Name or Material | UBCS039 |
| Grade | Research |
| SMILES | N12C(C(C3=CC=CN=C3)NC4=C2C=CC=C4)=CC=C1 |
| For Use With (Application) | Cancer-Kinase/protease |
| Percent Purity | 98.13% |
| CAS | 358721-70-7 |
| Solubility Information | DMSO : 100 mg/mL (404.38 mM; Need ultrasonic) |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C16H13N3 |
| Formula Weight | 247.29 |
Vincamine, MedChemExpress
MedChemExpress Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle.
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| Molecular Weight (g/mol) | 354.44 |
|---|---|
| Color | White |
| Physical Form | Solid |
| Chemical Name or Material | Vincamine |
| Grade | Research |
| SMILES | O=C(OC)[C@@]1(O)C[C@@]2(CC)[C@@]3([H])C(N1C4=CC=CC=C54)=C5CCN3CCC2 |
| For Use With (Application) | COVID-19-immunoregulation |
| Percent Purity | 99.76% |
| CAS | 1617-90-9 |
| Solubility Information | DMSO : 25 mg/mL (70.53 mM; Need ultrasonic) |
| Health Hazard 1 | H302 |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C21H26N2O3 |
| Formula Weight | 354.44 |
Ecopladib, MedChemExpress
MedChemExpress Ecopladib is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.
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PBOX 6, MedChemExpress
MedChemExpress PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule-depolymerizing agent and an apoptotic agent.
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| Molecular Weight (g/mol) | 396.44 |
|---|---|
| Color | White |
| Physical Form | Solid |
| Chemical Name or Material | PBOX 6 |
| Grade | Research |
| SMILES | O=C(OC1=C(C2=C3C=CC=CC3=CC=C2)OC4=CC=CC=C4N5C1=CC=C5)N(C)C |
| For Use With (Application) | Cancer-programmed cell death |
| Percent Purity | 98.0% |
| CAS | 290814-68-5 |
| Solubility Information | DMSO : 33.33 mg/mL (84.07 mM; Need ultrasonic) |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C25H20N2O3 |
| Formula Weight | 396.44 |
Dirlotapide, MedChemExpress
MedChemExpress Dirlotapide (CP742033) is a gut-selective inhibitor of microsomal triglyceride transfer protein (MTP) that reliably produces weight loss in obese dogs.
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MBQ-167, MedChemExpress
MedChemExpress MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively.
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| Molecular Weight (g/mol) | 338.41 |
|---|---|
| Color | Yellow |
| Physical Form | Solid |
| Chemical Name or Material | MBQ-167 |
| Grade | Research |
| SMILES | CCN1C2=C(C3=C1C=CC=C3)C=C(N4N=NC=C4C5=CC=CC=C5)C=C2 |
| For Use With (Application) | Cancer-Kinase/protease |
| Percent Purity | 99.26% |
| CAS | 2097938-73-1 |
| Solubility Information | DMSO : 155 mg/mL (458.02 mM; Need ultrasonic) |
| Health Hazard 1 | H302 |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C22H18N4 |
| Formula Weight | 338.41 |
EHop-016, MedChemExpress
MedChemExpress EHop-016 is a potent and selective Rac GTPase Rac1 and Rac3 inhibitor. EHop-016 inhibits Rac1 activity with an IC50 of 1.1 μM in MDA-MB-435 cells. EHop-016 inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration.
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| Molecular Weight (g/mol) | 430.55 |
|---|---|
| Color | Pink |
| Physical Form | Solid |
| Chemical Name or Material | EHop-016 |
| Grade | Research |
| SMILES | CCN1C2=C(C3=C1C=CC=C3)C=C(NC4=NC(NCCCN5CCOCC5)=NC=C4)C=C2 |
| For Use With (Application) | Cancer-Kinase/protease |
| Percent Purity | 99.43% |
| CAS | 1380432-32-5 |
| Solubility Information | DMSO : ≥ 32 mg/mL (74.32 mM) |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C25H30N6O |
| Formula Weight | 430.55 |
Mutated EGFR-IN-1, MedChemExpress
MedChemExpress Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.
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| Molecular Weight (g/mol) | 445.56 |
|---|---|
| Color | Pale Purple |
| Physical Form | Solid |
| Chemical Name or Material | Mutated EGFR-IN-1 |
| Grade | Research |
| SMILES | NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C |
| For Use With (Application) | Cancer-Kinase/protease |
| Percent Purity | 98.59% |
| CAS | 1421372-66-8 |
| Solubility Information | DMSO : ≥ 75 mg/mL (168.33 mM) |
| Synonym | Osimertinib analog |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C25H31N7O |
| Formula Weight | 445.56 |