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Novobiocin-Natriumsalz, Thermo Scientific Chemicals

Catalog No. 15493609
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Catalog No. 15493609 Lieferant Thermo Scientific Alfa Aesar Lieferanten-Nr. J60928.03
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Estimated Shipment: 20-11-2026
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Beschreibung

Topoisomerase II-Inhibitor

Topoisomerase II inhibitorNovobiocin sodium salt is effective an antistaphylococcal agent used in the treatment of Methicillin-resistant Staphylococcus aureus (MRSA). It is also used to inhibit the activity of retroviral RNA-dependent DNA polymerase as well as inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Novobiocin sodium salt, first isolated from Streptomyces nieveus, is a topoisomerase II inhibitor. It is a coumarin compound showing antibiotic activity
• Novobiocin sodium salt can inhibit DNA synthesis by inhibiting the topoisomerase II enzyme. Its antibacterial activity arises from competitive inhibition of the ATPase reaction catalyzed by the GyrB subunit

Application

• Novobiocin sodium salt is used to inhibit the activity of retroviral RNA-dependent DNA polymerase in laboratory experiments
• It is also used as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.
• Novobiocin sodium salt shows anti-staphylococcal activity against methicillin-resistant Staphylococcus aureus, a gram-positive bacterium
• It permits the relaxation of negative DNA supercoils and has been used to generate positively supercoiled DNA
• This compound inhibits the chaperone activity of Hsp90

TRUSTED_SUSTAINABILITY

Chemische Identifikatoren

CAS 1476-53-5
Summenformel C31H35N2NaO11
Molekulargewicht (g/mol) 634.61
MDL-Nummer MFCD00066541,MFCD00066541
InChI-Schlüssel AXOUUAINTJNFRS-UHFFFAOYNA-N
PubChem CID 131673945
IUPAC-Name Natrium 7-{[4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy}-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido]-8-methyl-2,4-dioxo-3,4-dihydro-2H-1-benzopyran-3-id
SMILES [Na+].COC1C(OC(N)=O)C(O)C(OC2=CC=C3C(=O)[C-](NC(=O)C4=CC=C(O)C(CC=C(C)C)=C4)C(=O)OC3=C2C)OC1(C)C

Spezifikation

Chemischer Name oder Material Novobiocin sodium salt
Typ Novobiocin Sodium Salt
Physikalische Form Pulver
Schmelzpunkt 215°C
Farbe Braun bis weiß
Menge 1 g
Beilstein 3892910
Merck Index 14,6722
Löslichkeitsinformationen Soluble in water at 100mg/ml; Also soluble in ethanol or DMSOSoluble in water,ethanol,dimethyldulfoxide and methanol.
Formelmasse 634.61

RUO – Research Use Only

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