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Camostat methanesulfate, 98%

Catalog No. 15444759
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Catalog No. 15444759 Lieferant Thermo Scientific Alfa Aesar Lieferanten-Nr. J62362.ME
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Description

An orally active synthetic serine protease inhibitor | CAS: 59721-29-8 | C21H26N4O8S | 494.52 g/mol

It is used as a protease and Trypsin inhibitor. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It is used as a protease and Trypsin inhibitor. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.

Solubility
Soluble in water (100 mM), DMSO (100 mM), and ethanol (<1mg/mL).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 59721-29-8
Summenformel C21H26N4O8S
Molekulargewicht (g/mol) 494.52
MDL-Nummer MFCD00941410
InChI-Schlüssel FSEKIHNIDBATFG-UHFFFAOYSA-N
Synonym camostat mesylate, camostat mesilate, camostat methanesulfonate, camostat monomethanesulfonate, foipan, unii-451m50a1eq, dsstox_cid_238, dsstox_rid_75452, dsstox_gsid_20238
PubChem CID 5284360
IUPAC-Name 4-{2-[(dimethylcarbamoyl)methoxy]-2-oxoethyl}phenyl 4-[(diaminomethylidene)amino]benzoate; methanesulfonic acid
SMILES CS(O)(=O)=O.CN(C)C(=O)COC(=O)CC1=CC=C(OC(=O)C2=CC=C(C=C2)N=C(N)N)C=C1

Specifications

Chemischer Name oder Material Camostat methanesulfate
Schmelzpunkt 164°C to 168°C
Farbe Weiß
Menge 500 mg
Merck Index 14,1728
Löslichkeitsinformationen Soluble in water (100 mM),DMSO (100 mM),and ethanol (<1mg/ml).
Formelmasse 494.52
Reinheit (%) 98%
Physikalische Form Pulver

RUO – Research Use Only

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