TOX Rat anti-Human, Mouse, PE, Clone: TXRX10, eBioscience™
Rat Monoclonal Antibody
Marke: Affymetrix eBioscience 12-6502-82
Weitere Details : Gewicht : 0.25000kg
BeschreibungExcitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|TOX1, thymocyte selection-associated high mobility group box protein TOX, thymus high mobility group box protein TOX|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.