PSA-NCAM Mouse anti-Human, Mouse, Rat, Clone: 12E3, eBioscience™
Mouse Monoclonal Antibody
Marke: Affymetrix eBioscience 14-9118-82
Weitere Details : Gewicht : 0.09500kg
BeschreibungIt is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Polysialic acid is a long homopolymer of sialic acid that is negatively charged and is attached to neural cell adhesion molecule (CD56) and serves as a regulator of NCAM function. PSA attachment to NCAM is associated with inhibited adhesion of neural cells. PSA-NCAM expression is highly regulated and corresponds to specific neural developmental windows in which neural precursors are migrating and during the process of axonal sprouting, guidance, and targeting. PSA-NCAM expression is prevalent during development of the brain, but in the adult becomes restricted to regions undergoing self-renewal or exhibiting plasticity such as the olfactory bulb, suprachiasmatic nucleus, hippocampus, hypothalamus, and specific spinal cord nuclei. PSA-NCAM is re-expressed during tumorigenesis and is also expressed on cell lines isolated from neuroblastomas and pheochromocytomas.
|PBS with 0.09% sodium azide; pH 7.2|
|P13596, P13595, P13591|
|CD56; NCAM1; Neural cell adhesion molecule 1; NCAM-1; Polysialylated-neural cell adhesion molecule; Polysialylated NCAM; PSA NCAM|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|17967, 24586, 4684|
For Research Use Only.