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![Invitrogen™ MERTK (cMER) [A708S] Recombinant Human Protein:](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-650.jpg)
Invitrogen™ MERTK (cMER) [A708S] Recombinant Human Protein
MERTK (c-MER) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family. Recombinant human MERTK A708S (578-872) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
492.00 € - 7490.00 €
Specifications
| For Use With (Application) | Enzyme and Protein Activity Assay, Industrial and Applied Science, Kinase Assay, Kinase Biology, Kinase Proteins and Expression Reagents, Pharma and Biopharma, Protein Assays and Analysis, Protein Biology, Target and Lead Identification and Validation |
|---|---|
| Formulation | 50mM Tris-HCl pH 7.5, 150mM NaCl, 0.25mM DTT, 10mM glutathione, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol |
| Molecular Weight (g/mol) | 60.2kDa |
| Storage Requirements | Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. |
| Gene Alias | MERTK |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15478963
|
Invitrogen™
PV6325 |
10μg |
492.00 €
10µg |
Estimated Shipment: 29-04-2024 Log in to see stock. |
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|
15488963
|
Invitrogen™
PV6326 |
100μg |
1678.00 €
100µg |
Estimated Shipment: 29-04-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
|
15498963
|
Invitrogen™
PV6327 |
1mg |
7490.00 €
1mg |
Estimated Shipment: 29-04-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
MERTK (c-MER) encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Cytokine-dependent activation of TAM signaling diverts a proinflammatory pathway to provide an intrinsic feedback inhibitor of both TLR- and cytokine-driven immune responses. MERTK is essential regulators of mammalian spermatogenesis. Mutations in MERTK gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
- Validated in LanthaScreen™ Kinase Binding Assay
- Protocols available for simple use and optimized performance
- Multiple pack sizes available for convenient use
Specifications
| Enzyme and Protein Activity Assay, Industrial and Applied Science, Kinase Assay, Kinase Biology, Kinase Proteins and Expression Reagents, Pharma and Biopharma, Protein Assays and Analysis, Protein Biology, Target and Lead Identification and Validation | |
| 60.2kDa | |
| MERTK | |
| Human | |
| GST Tag |
| 50mM Tris-HCl pH 7.5, 150mM NaCl, 0.25mM DTT, 10mM glutathione, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol | |
| Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. | |
| aa 578-872 | |
| Recombinant |