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MERTK Rat anti-Mouse, Clone: DS5MMER, eBioscience™

Rat Monoclonal Antibody

Marke:  Affymetrix eBioscience 14-5751-80

Weitere Details : Gewicht : 0.09500kg

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Artikelnummer. 15527456

  • 85.25 € / 25 Mikrogramm


Verfügbar ab
09-10-2020
Zum Warenkorb hinzufügen

Beschreibung

Beschreibung

The DS5MMER antibody also works in western blotting and immunoprecipitation. Applications Reported: This DS5MMER antibody has been reported for use in flow cytometric analysis, immunohistochemical staining, immunohistochemical staining of frozen tissue sections, western blotting and immunoprecipitation. Fluorochrome-conjugated DS5MMER is recommended for use in flow cytometry. Applications Tested: This DS5MMER antibody has been tested by immunohistochemistry on frozen mouse tissue and can be used at less than or equal to 5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Spezifikation

Spezifikation

MERTK
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q60805
MER, MGC133349, RP38, c-mer
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation
DS5MMER
Unconjugated
Mertk
Liquid
Mertk
IgG2a, kappa
25 μg
4° C
Primary
17289
Videos
Dokumentation

For Research Use Only.