IRF8 Mouse anti-Human, Mouse, APC, Clone: V3GYWCH, eBioscience™
Mouse Monoclonal Antibody
Marke: Affymetrix eBioscience 17-9852-80
Weitere Details : Gewicht : 0.09500kg
BeschreibungCell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|H-ICSBP, ICSBP, ICSBP1, IRF-8|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.