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IRF8 Mouse anti-Human, Mouse, APC, Clone: V3GYWCH, eBioscience™

Mouse Monoclonal Antibody

Marke:  Affymetrix eBioscience 17-9852-80

Weitere Details : Gewicht : 0.09500kg

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Artikelnummer. 15528266

  • 125.00 € / 25 Mikrogramm


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Beschreibung

Beschreibung

Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
Spezifikation

Spezifikation

IRF8
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P23611, Q02556
H-ICSBP, ICSBP, ICSBP1, IRF-8
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human, Mouse
Flow Cytometry
V3GYWCH
APC
IRF8
Liquid
Irf8
IgG1, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
15900, 3394
Videos
Dokumentation

For Research Use Only.