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IL-12/IL-23 p40 Mouse anti-Human, Clone: C8.6, eBioscience™

Mouse Monoclonal Antibody

Marke:  Affymetrix eBioscience 14-7129-85

Weitere Details : Gewicht : 0.01000kg

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Artikelnummer. 15238027

  • 208.00 € / 500 Mikrogramm


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Beschreibung

Beschreibung

IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintece and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.
Spezifikation

Spezifikation

IL-12/IL-23 p40
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P29460
IL12B; Il12p40; interleukin 12B; RP23-388G23.1; Il-12b; Il-12p40; p40; IL-12 p40; IL-23 subunit p40; IL12P40
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Functional Assay, Neutralization, Western Blot
C8.6
Unconjugated
IL12B
Liquid
IL12B
IgG1, kappa
500 μg
4° C
Primary
3593
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