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FOXP3 Rat anti-Bovine, Canine, Feline, Mouse, Porcine, Rat, Clone: FJK-16s, eBioscience™

Rat Monoclonal Antibody

Marke:  Affymetrix eBioscience 14-5773-80

Weitere Details : Gewicht : 0.01000kg

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Artikelnummer. 15237457

  • 166.00 € / 25 Mikrogramm


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Beschreibung

Beschreibung

Applications Tested: This FJK-16s antibody has been tested by immunoblotting (WB) (1-5 µ/mL) of mouse splenocytes. The FJK-16s antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded mouse tissue using low or high pH antigen retrieval and can be used at less than or equal to 5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
Spezifikation

Spezifikation

Foxp3
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q99JB6
AIID, DIETER, Forkhead box P3, foxp3, IPEX, JM2, PIDX, SCURFIN, XPID
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Bovine, Canine, Feline, Mouse, Porcine, Rat
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
FJK-16s
Unconjugated
Foxp3
Liquid
FOXP3
IgG2a, kappa
25 μg
4° C
Primary
100037405, 20371, 317382, 444998, 491876, 506053
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