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Estrogen Receptor beta Mouse anti-Human, Clone: MC10, eBioscience™

Mouse Monoclonal Antibody

Marke:  Affymetrix eBioscience 14-9336-82

Weitere Details : Gewicht : 0.09500kg

 Weitere Artikel aus diesem Sortiment

Artikelnummer. 15527596

  • 289.00 € / 100 Mikrogramm


Verfügbar ab
27-10-2020
Zum Warenkorb hinzufügen

Beschreibung

Beschreibung

Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms domitly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
Spezifikation

Spezifikation

Estrogen Receptor beta
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q92731
ER Beta, ER, ESR2, ESR-Beta
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
MC10
Unconjugated
ESR2
Liquid
ESR2
IgG2a, kappa
100 μg
4° C
Primary
2100
Videos
Dokumentation

For Research Use Only.