Invitrogen™ Silencer™ Human Cell Surface siRNA Library

Description

Cell surface receptors are specialized integral membrane proteins that take part in communication between the cell and its surroundings. Extracellular signaling molecules, typically hormones, neurotransmitters, cytokines, growth factors and cell recognition molecules, attach to the receptor, triggering changes in the function of the cell. The Silencer™ Human Cell Surface siRNA Library contains 2,367 Ambion™ Silencer siRNAs targeting 789 genes. This library was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC).

Why use the Silencer Human Cell Surface siRNA Library?Together with careful bioinformatics selection of gene targets, Silencer siRNAs are optimized with design and high quality synthesis with guaranteed silencing. The Silencer Human Cell Surface siRNA Library contains our pre-designed and when available, validated siRNAs generated with maximum potency and specificity in mind so you can focus on data quality. All Silencer libraries are selected against the latest available databases and resources for up-to-date content. Full siRNA sequence information, as well as the exon targeted and each targeted gene's symbol, full name, aliases, RefSeq number, and Locus ID, plus results from any validation experiments performed using the included siRNAs is provided. Please contact us for the complete list of targets.Silencer siRNA libraries allow you to screen efficiently and maximize data outputInvitrogen Silencer siRNAs are designed with potency in mind to help ensure gene knockdown at minimum concentrations. This not only helps ensure less potential for off target effects and false positive data but also minimizes false negative outcomes of siRNA screening. The Silencer Human Cell Surface siRNA Library contains 0.25 nmol of each siRNA, sufficient for 100 transfections (at 25 nM siRNA, 100 μL transfection volume).
Utilizing Invitrogen Silencer technology built on stringent bioinformatics to enable high target specificity and siRNA potency, the Silencer Human Cell Surface siRNA Library is an ideal solution for focused and cost-effective RNAi screening against cell surface-based signaling.

• Comprehensive—Expedite your cell surface receptor RNAi functional screens with pre-defined Silencer Human Cell Surface siRNA Library
• Reliable—Increase target screening accuracy with three individual siRNAs per gene target
• Effective—Reduce off target impacts at low concentrations with proven Invitrogen Silencer siRNA design
• Convenient—Reduce data de-convolution and accelerate target validation with our arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formats