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DELE Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Thermo Scientific PA557712
Additional Details : Weight : 0.02000kg
Description
Immunogen sequence: PLDRFFSSPL WHPCSSLRQH ILPSPDGPAP RHTGLREPRL GQEEASAQPR NFSHNSLRGA RPQDPSEEGP GDFGFLHASS SIESEAKPAQ P Highest antigen sequence identity to the following orthologs: Mouse - 55%, Rat - 59%.
DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-Alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-Alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.Specifications
| DELE | |
| Polyclonal | |
| Unconjugated | |
| KIAA0141 | |
| DELE, Death ligand signal enhancer, KIAA0141 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 9812 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry | |
| 0.3 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q14154 | |
| KIAA0141 | |
| Recombit protein corresponding to Human DELE | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
Research Use Only