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CD5 Monoclonal Antibody (53-7.3), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

103.00 € - 205.00 €

Specifications

Antigen CD5
Clone 53-7.3
Concentration 0.5 mg/mL
Applications Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Classification Monoclonal
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Products 2
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Product Code Brand Quantity Price Quantity & Availability  
15226767
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Affymetrix eBioscience
14-0051-82
100 μg
103.00 €
100µg
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15236767
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Affymetrix eBioscience
14-0051-85
500 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The 53-7.3 monoclonal antibody reacts with mouse CD5, a 67 kDa protein expressed by a majority of thymocytes, mature T cells and a subset of B cells. The expression of CD5 by a small subset of B cells characterizes a developmentally and functionally distinct lineage of B cells called B-1 cells. CD5 is a counter-receptor for CD72 and plays a role in the T-B cell interaction. Applications Reported: The 53-7.3 antibody has been reported for use in flow cytometric analysis, immunoprecipitation, and immunohistochemical staining. Applications Tested: The 53-7.3 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome.
Specifications

Specifications

CD5
0.5 mg/mL
Monoclonal
Liquid
RUO
P13379
Cd5
Primary
4° C
Cd5
53-7.3
Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Unconjugated
Rat
Mouse
12507
IgG2a κ
Affinity chromatography
Antibody
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SDS
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Documents

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