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CD36, clone: eBioNL07 (NL07), eBioscience™

Mouse Monoclonal Antibody

Marke:  Affymetrix eBioscience 14-0369-82

Weitere Details : Gewicht : 0.01000kg

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Artikelnummer. 15296917

  • 135.00 € / 100 Mikrogramm


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Beschreibung

Beschreibung

Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. CD36 (fatty acid translocase, FAT) is an 88 kDa, ditopic glycosylated protein that belongs to the class B family of scavenger receptors. CD36 is expressed by most resting marginal zone B cells but not by follicular and B1 B cells, and is rapidly induced on Follicular B cells in vitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. Similar to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chain fatty acids. CD36 is preferentially found within lipid rafts, which facilitates its association with receptors, signaling and adapter molecules. CD36 binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. Further, CD36 may function as a cell adhesion molecule and directly mediates cyto-adherence of Plasmodium falciparum parasitized erythrocytes. Mutations in the CD36 gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the CD36 protein have been found.
Spezifikation

Spezifikation

CD36
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P16671
FAT, GPIV, Scarb3, GPIIIB, PAS IV, PAS-4, fatty acid translocase, glycoprotein IIIb, platelet glycoprotein 4, platelet glycoprotein IV
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
eBioNL07 (NL07)
Unconjugated
CD36
Liquid
CD36
IgM
100 μg
4° C
Primary
948
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