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CD279 (PD-1) Mouse anti-Human, PE, Clone: MIH4, eBioscience™

Mouse Monoclonal Antibody

Marke:  Affymetrix eBioscience 12-9969-42

Weitere Details : Gewicht : 0.23750kg

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Artikelnummer. 15527296

  • 243.00 € / 100 Tests


Auf Lager: 5
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Beschreibung

Beschreibung

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of ""danger signals"" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Spezifikation

Spezifikation

CD279 (PD-1)
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
Q15116
PD1
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
MIH4
PE
PDCD1
Liquid
PDCD1
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
5133
Videos
Dokumentation

For Research Use Only.