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CD278 (ICOS) Monoclonal Antibody (C398.4A), FITC, eBioscience™, Invitrogen™

Armenian Hamster Monoclonal Antibody

92.00 € - 189.00 €

Specifications

Antigen CD278 (ICOS)
Clone C398.4A
Concentration 0.5 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15228399
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Affymetrix eBioscience
11-9949-80
25 μg
92.00 €
25µg
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Estimated Shipment: 07-05-2024
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15238399
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Affymetrix eBioscience
11-9949-82
100 μg
189.00 €
100µg
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Estimated Shipment: 09-04-2024
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Description

Description

Description: The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells. C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells. It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS. The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL). Applications Reported: The C398.4A antibody has been reported for use in flow cytometric analysis. Applications Tested: The C398.4A antibody has been tested by flow cytometric analysis of Con A-stimulated mouse splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL.

ICOS (CD278) encodes a protein that is a member of the CD28 and CTLA-4 cell-surface receptor family. It functions as a homodimer and has a crucial role in cell-cell signaling, immune responses, and the regulation of cell proliferation. ICOS has been linked to various disorders, including Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency.
Specifications

Specifications

CD278 (ICOS)
0.5 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; CVID1; H4; Icos; inducible costimulator; inducible T cell costimulator; inducible T cell co-stimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Ly115
ICOS
Primary
4° C, store in dark, DO NOT FREEZE!
ICOS
C398.4A
Flow Cytometry
FITC
Armenian Hamster
Mouse, Rat, Rhesus Monkey
Q9R1T7, Q9WVS0
54167, 64545, 705788
IgG
Affinity chromatography
Antibody
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For Research Use Only.