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CD274 (PD-L1, B7-H1) Monoclonal Antibody (1-111A), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

110.00 € - 223.00 €

Specifications

Antigen CD274 (PD-L1, B7-H1)
Clone 1-111A
Concentration 0.5 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
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Product Code Brand Quantity Price Quantity & Availability  
15238297
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Affymetrix eBioscience
14-9971-82
100 μg
223.00 €
100µg
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15228297
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Affymetrix eBioscience
14-9971-81
50 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The 1-111A monoclonal antibody reacts with mouse B7-H1, also known as PD-L1. B7-H1, a member of the B7 family, has a predicted molecular weight of approximately 40 kDa and belongs to the Ig superfamily. B7-H1 is expressed on a majority of leukocytes including T, B, NK and DC. B7-H1 is a ligand for PD-1. Interaction of PD-1 with either PD-L1 (B7-H1) or PD-L2 (B7-DC) results in inhibition of T and B cell responses. Preliminary testing suggests that 1-111A and MIH5 (Cat. No. 14-5982) cross-block each other. Applications Reported: The 1-111A antibody has been reported for use in flow cytometric analysis. Applications Tested: The 1-111A antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
Specifications

Specifications

CD274 (PD-L1, B7-H1)
0.5 mg/mL
Monoclonal
Liquid
RUO
Q9EP73
Cd274
Primary
4° C
Cd274
1-111A
Flow Cytometry
Unconjugated
Rat
Mouse
60533
IgG2a κ
Affinity chromatography
Antibody
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