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CD209 (DC-SIGN), clone: LWC06, eBioscience™

Rat Monoclonal Antibody

Marke:  Affymetrix eBioscience 14-2092-82

Weitere Details : Gewicht : 0.01000kg

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Artikelnummer. 15297307

  • 219.00 € / 100 Mikrogramm


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von Anbieter 30-05-2018
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Beschreibung

Beschreibung

Description: The LWC06 antibody was generated by immunization with the recombinant extracellular region of mouse CIRE/DC-SIGN (CD209). CIRE/DC-SIGN was identified by its expression on CD8 alpha- dendritic cells and plasmacytoid predendritic cells, and is the closest homologue of human DC-SIGN. Human DC-SIGN was originally identified in human placenta for its ability to bind the HIV envelope protein gp120 in a CD4-independent manner. CIRE/DC-SIGN is a 33kDa type II transmembrane C-type lectin protein. It contains a C-terminal, extracellular, Carbohydrate Recognition Domain (CRD) that is predicted to bind mannose and other carbohydrates in a calcium dependent manner. It has been postulated that CIRE/DC-SIGN may play a role in T-dendritic cell interactions through binding with members of the ICAM family. CIRE/DC-SIGN is differentially expressed by sub-populations of dendritic cells and preliminary data suggest that its expression varies depending on the activation state of the host. CIRE/DC-SIGN is down-regulated in spleen-derived dendritic cell cultures supplemented with GM-CSF. While human DC-SIGN is predominantly expressed in dendritic cells, CIRE/DC-SIGN mRNA has also been detected in B cells. The LWC06 monoclonal antibody does not cross-react with the closely related SIGNR1, SIGNR2, SIGNR3 or SIGNR4.CD209 protein is sensitive to collagenase treatment.Applications Reported: This LWC06 antibody has been reported for use in immunoprecipitation, and immunoblotting (WB).Applications Tested: This LWC06 antibody has been tested by immunoblotting and immunoprecipitation of CIRE in CIRE-transfected CHO cells. The reactivity of this antibody has been confirmed by immunoprecipitation of CIRE with LWC06 followed by immunoblotting with another CIRE-specific monoclonal antibody, 5H10 (cat. 14-2091) and, immunoprecipitation of CIRE with 5H10 followed by immunoblotting with LWC06.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Spezifikation

Spezifikation

CD209 (DC-SIGN)
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q91ZX1
CD209, CDSIGN, CIRE, DC-SIGN, DC-SIGN1, Dcsign, MGC130443, SIGN-R1, SIGNR5, CD209a
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
Western Blot
LWC06
Unconjugated
Cd209a
Purified
Cd209a
IgG2a
100μg
Store at 2-8°C.
Primary
170786
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