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CD158f Mouse anti-Human, APC, Clone: UP-R1, eBioscience™

Mouse Monoclonal Antibody

Marke:  Affymetrix eBioscience 17-1588-41

Weitere Details : Gewicht : 0.23750kg

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Artikelnummer. 15528026

  • 151.00 € / 25 Tests


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von Anbieter 26-03-2020
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Beschreibung

Beschreibung

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several ""framework"" genes are found in all haplotypes. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Spezifikation

Spezifikation

CD158f
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
Q8N109
KIR2DL, CD158, NKAT, NKAT1
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
UP-R1
APC
KIR2DL5A
Liquid
KIR2DL5A
IgG1
25 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
57292
Videos
Dokumentation

For Research Use Only.