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CD117 (c-Kit) Rat anti-Mouse, Clone: ACK2, eBioscience™

Rat Monoclonal Antibody

Marke:  Affymetrix eBioscience 14-1172-85

Weitere Details : Gewicht : 0.01000kg

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Artikelnummer. 15227187

  • 221.00 € / 500 Mikrogramm


Verfügbar ab
04-12-2020
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Beschreibung

Beschreibung

Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras-Raf-ERK1&2 signaling pathway.
Spezifikation

Spezifikation

CD117 (c-Kit)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P05532
C-Kit, CD117, PBT, SCFR, mast/stem cell growth factor receptor Kit, p145 c-kit, piebald trait protein, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, soluble KIT variant 1, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, ckit
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
ACK2
Unconjugated
Kit
Liquid
Kit
IgG2b, kappa
500 μg
4° C
Primary
16590
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.