missing translation for 'onlineSavingsMsg'
Learn More

Invitrogen™ Human CCL4 (MIP-1 beta) Synthetic Peptide

Synthetic Peptide

Brand:  Invitrogen™ PEP1552

Additional Details : Weight : 0.01000kg

Product Code. 15245479

  • 130.00 € / 50µg
Estimated Shipment: 12-04-2024
to see stock.

Please to purchase this item. Need a web account? Register with us today!


For Research Use Only. All usage must comply with product instructions.


Description

Description

CCL4 Synthetic Peptide, PEP-1552, from Invitrogen.

CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis. CCL4 is produced by macrophages upon stimulation by bacterial endotoxins. CCL4 recruits and stimulates various inflammatory cells at sites of inflammation. CCL4 is produced by lymphocytes, macrophages and dendritic cells. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ, with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells. CCL4 binds with high affinity to CCR5 receptors. This peptide corresponds to 15 amino acids near the center of human CCL4.PEP-1552 can be used as a blocking peptide with polyclonal antibody PA5-34509.
Specifications

Specifications

6351
purified
Human CCL4 (MIP-1 beta)
-20°C
Liquid
Blocking Assay, Control
No
Peptide
RUO - research use only
Human
P13236
200 μg/mL
Synthetic Peptide
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
CCL4
0.02% sodium azide
50 μg
PBS
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Promotions

Promotions