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Bcl-2 Mouse anti-Mouse, Rat, Clone: 10C4, eBioscience™

Mouse Monoclonal Antibody

Marke:  Affymetrix eBioscience 14-6992-82

Weitere Details : Gewicht : 0.01000kg

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Artikelnummer. 15237967

  • 164.00 € / 100 Mikrogramm


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von Anbieter 03-07-2019
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Beschreibung

Beschreibung

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
Spezifikation

Spezifikation

Bcl-2
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P49950, P10417
AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse, Rat
Flow Cytometry, Immunoprecipitation, Western Blot
10C4
Unconjugated
Bcl2
Liquid
Bcl2
IgG1, kappa
100 μg
4° C
Primary
12043, 24224
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