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B7-H4 Mouse anti-Human, APC, Clone: H74, eBioscience™

Mouse Monoclonal Antibody

Marke:  Affymetrix eBioscience 17-5949-41

Weitere Details : Gewicht : 0.23750kg

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Artikelnummer. 15528166

  • 113.00 € / 25 Tests


Verfügbar ab
27-10-2020
Zum Warenkorb hinzufügen

Beschreibung

Beschreibung

B7-H4 (B7x, VTCN1) a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 is expressed primarily on the membrane of lymphoid cells, and as an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, it is involved in mediating cellular and humoral immune responses. Overexpression of B7-H4 is associated with certain maligcies, including ovarian and breast cancer, which may be a mechanism by which tumor cells suppress T cell immunity and facilitate tumor progression. Further, VTCN1 may be a useful biomarker for the early detection of ovarian cancer and Renal Cell Carcinoma (RCC).
Spezifikation

Spezifikation

B7-H4
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
Q7Z7D3
B7-H4, B7H4, B7S1, B7X, B7h.5, FLJ22418, PRO1291, RP11-229A19.4, VCTN1
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
H74
APC
VTCN1
Liquid
VTCN1
IgG1, kappa
25 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
79679
Videos
Dokumentation

For Research Use Only.