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Osteopontin Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA516821
Additional Details : Weight : 0.01000kg
Description
PA5-16821 targets Osteopontin in IHC (P) applications and shows reactivity with Canine, Human, and Porcine samples. The PA5-16821 immunogen is a synthetic peptide derived from internal domain of human Osteopontin.
Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in maligt glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.Specifications
| Osteopontin | |
| Polyclonal | |
| PBS with 1% BSA and 0.1% sodium azide; pH 7.6 | |
| P10451 | |
| SPP1 | |
| A synthetic peptide derived from internal domain of human Osteopontin | |
| 500 μL | |
| Primary | |
| Human, Porcine | |
| Antibody | |
| IgG |
| Immunohistochemistry (Paraffin), Western Blot | |
| Unconjugated | |
| SPP1 | |
| SPP-1, SPP1/CALPHA1 fusion, bone sialoprotein 1, bone sialoprotein I, early T-lymphocyte activation 1, nephropontin, osteopontin, osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), secreted phosphoprotein-1 (osteopontin, bone sialoprotein), urinary stone protein, uropontin | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 6696 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |